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References

Our partners

ez

Pharmaceutical partners

  • Richter Gedeon NyRt. (2006 - currently)
  • TEVA (2009 - currently)
  • EGIS Nyrt. (2010 - currently)
  • Roche (2008 - currently)
  • sanofi-aventis / Chinoin (2010 - 2011)
  • AstraZeneca (2006 - 2007)
  • Pfizer Global Research (2001 - 2004)

 

Life Science Research partners

Kp4

  • Diagenode SA (2008 - currently)
  • Millipore (2008 - currently)
  • BioSystems International SAS (2005 - currently)
  • Astrid Research (2007 - currently)
  • InnoTears Kft. (2007 - currently)
  • Premier Research GmbH (2009 - currently)
  • University of Debrecen Technology Transfer Office (2007 - currently)

 

Kp2

Academic partners

  • University of Debrecen (since foundation)
  • National Institute of Oncology (2008 - currently)
  • Hungarian Clinical Neurogenetic Society (2007 - currently)
  • Hungarian Academy of Science Biological Research Center (2010)
  • University of Szeged (2010)
  • Semmelweis University (2007 - 2009)
  • University of Pécs(2007 - 2009)
  • Dekut NPO (2009)

 

Kp3

Trading partners

  • Affymetrix (2009 - currently)
  • Applied Biosystems (2008 - currently)
  • Biomedica (2007 - currently)

 

Before 2007 we provided our services as a functional part of Clinical Genomic Centre of University of Debrecen.

 

Most important publications

László Nagy

      1. Töröcsik, D., Baráth, M., Benkő, S., Széles, L., Dezső, B.,  Póliska, S.,  Hegyi, Z., Homolya, L.,  Szatmári, I.,  Lányi A.,  and  Nagy, L. Activation of LXR sensitizes human dendritic cells to inflammatory stimuli. Journal of Immunology 184:5456-5465  (2010)
      2. Széles, L.,  Keresztes, G., Töröcsik, D., Balajthy, Z., Krenács, L., Póliska, S.,  Steinmeyer, A., Zuegel, A., Pruenster, M., Rot, A. and Nagy, L. 1,25-dihydroxyvitaminD3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype. Journal of Immunology 182(4):2074-2083 (2009)
      3. Szatmari, I. and Nagy, L. Nuclear receptor signaling in dendritic cells connects lipids, the genome and immune function. The EMBO Journal 27(18):2353-2362  (2008)
      4. Szatmari, I.,  Töröcsik, D.,  Agostini, M., Nagy, T., Gurnell, M.,  Barta, E., Chatterjee, K.K.V. and  Nagy, L. PPARgamma regulates the function of human dendritic cells primarily by altering lipid metabolism. Blood 110:3271-3280 (2007)
      5. Szatmari, I., Pap, A., Ruehl, R., Ma, J.X., Illarionov, P.A., Besra, G.S., Rajnavolgyi, E., Dezso, B. and  Nagy, L. PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. Journal of Experimental Medicine 203:2351-2362 (2006)
      6. Nagy, L. and Schwabe J.W.R. The mechanism of nuclear receptor molecular switch. Trends in Biochemical Sciences 29(6):317-324  (2004)
      7. Szatmari, I., Gogolak, P., Im, S. J., Dezso, B., Rajnavolgyi, E. and Nagy, L. Activation of PPARgamma specifies a dendritic cell subtype capable of enhanced induction of iNKT cell expansion. Immunity 21:95-106 (2004)
      8. Nagy, L., Kao H-Y., Love, JD, , Li, C., Banayo, E., Gooch, JT., Chatterjee, VKK, Evans, RM and Schwabe, JWR. Mechanism of co-repressor binding and release from nuclear hormone receptors. Genes and Development 13(24): 3209-3216 (1999)
      9. Nagy, L., Tontonoz, P., Alvarez, JGA., Chen, H. and Evans, RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 93(2): 229 -240 (1998)
      10. Nagy, L., Kao, H-Y., Chakravarti, D.,  Lin, R.J.,  Hassig, C.A.,  Ayer, D.E., Schreiber, S.L. and Evans, R.M. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A and histone deacetylase. Cell 89 (3): 373-380 (1997)

          Gábor Zahuczky

            1. Inczédy-Farkas G, Benkovits J, Balogh N, Almos P, Scholtz B, Zahuczky G, Török Z, Nagy K, Réthelyi J, Makkos Z, Kassai-Farkas A, Egerházy A, Tuzko J, Janka Z, Bitter I, Németh G, Nagy L, Molnár MJ. SCHIZOBANK - The Hungarian national schizophrenia biobank and its role in schizophrenia research.Orv Hetil. 2010 Aug 29;151(35):1403-8. Hungarian.
            2. Varga I, Hutóczki G, Petrás M, Scholtz B, Mikó E, Kenyeres A, Tóth J, Zahuczky G, Bognár L, Hanzély Z, Klekner A. Expression of Invasion-Related Extracellular Matrix Molecules in Human Glioblastoma Versus Intracerebral Lung Adenocarcinoma Metastasis. Cen Eur Neurosurg. 2010 Apr 15.
            3. Petrovski G, Zahuczky G, Majai G, Fesus L. Phagocytosis of cells dying through autophagy evokes a pro-inflammatory response in macrophages. Autophagy. 2007 Sep-Oct;3(5):509-11. Epub 2007 Jul 13.
            4. Sperka T, Miklossy G, Tie Y, Bagossi P, Zahuczky G, Boross P, Matuz K, Harrison RW, Weber IT, Tozser J. Bovine leukemia virus protease: comparison with human T-lymphotropic virus and human immunodeficiency virus proteases. J Gen Virol. 2007 Jul;88(Pt 7):2052-63.
            5. Majai G, Sarang Z, Csomos K, Zahuczky G, Fesus L. PPARgamma-dependent regulation of human macrophages in phagocytosis of apoptotic cells. Eur J Immunol. 2007 May;37(5):1343-54.
            6. Petrovski G, Zahuczky G, Katona K, Vereb G, Martinet W, Nemes Z, Bursch W, Fesus L. Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes. Cell Death Differ. 2007 Jun;14(6):1117-28. Epub 2007 Mar 16.
            7. Bagossi P, Sperka T, Feher A, Kadas J, Zahuczky G, Miklossy G, Boross P, Tozser J. Amino acid preferences for a critical substrate binding subsite of retroviral proteases in type 1 cleavage sites. J Virol. 2005 Apr;79(7):4213-8.
            8. Tozser J, Bagossi P, Zahuczky G, Specht SI, Majerova E, Copeland TD. Effect of caspase cleavage-site phosphorylation on proteolysis Biochem J. 2003 May 15;372(Pt 1):137-43.
            9. Tozser J, Zahuczky G, Bagossi P, Louis JM, Copeland TD, Oroszlan S, Harrison RW, Weber IT. Comparison of the substrate specificity of the human T-cell leukemia virus and human immunodeficiency virus proteinases. Eur J Biochem. 2000 Oct;267(20):6287-95.
            10. Zahuczky G, Boross P, Bagossi P, Emri G, Copeland TD, Oroszlan S, Louis JM, Tozser J. Cloning of the bovine leukemia virus proteinase in Escherichia coli and comparison of its specificity to that of human T-cell leukemia virus proteinase. Biochim Biophys Acta. 2000 Mar 16;1478(1):1-8.

              Bálint László Bálint

              1. Dozsa, A; Dezso, B; Toth, BI; et al. PPAR gamma has different expression and signaling pattern in normal and pathologic sebaceous glands. JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 129 Pages: S54-S54, 2009
              2. Itoh, T; Fairall, L; Amin, K; et al. Structural basis for the activation of PPAR gamma by oxidized fatty acids. NATURE STRUCTURAL & MOLECULAR BIOLOGY Volume: 15 Issue: 9 Pages: 924-931, 2008
              3. Szekvolgyi, L; Rakosy, Z; Balint, BL; et al. Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNA. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Volume: 104 Pages: 14964-14969, 2007
              4. Szekvolgyi, L; Balint, BL; Imre, L; et al. ChIP-On-Beads: Flow-cytometric evaluation of chromatin immunoprecipitation. CYTOMETRY PART A Volume: 69A Issue: 10 Pages: 1086-1091, Oct. 1. 2006
              5. Szatmari, I; Vamosi, G; Brazda, P; et al. Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells. JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 281 Issue: 33 Pages: 23812-23823, 2006
              6. Balint, BL; Szanto, A; Madi, A; et al. Arginine methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells. MOLECULAR AND CELLULAR BIOLOGY Volume: 25 Issue: 13 Pages: 5648-5663, Jul. 2005
              7. Balint, BL; Gabor, P; Nagy, L Genome-wide localization of histone 4 arginine 3 methylation in a differentiation primed myeloid leukemia cell line. IMMUNOBIOLOGY Volume: 210 Issue: 2-4 Pages: 141-152, 2005
              8. Balint, BL, Nagy, L Genome-wide location analysis of nuclear receptors. FEBS JOURNAL Volume: 272 Pages: 482-482, 2005
              9. Balint, BL, Nagy, L Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases. Endocr Metab Immune Disord Drug Targets. 2006 Mar;6(1):33-4

              Beáta Scholtz

              1. Tóth K, Sarang Z, Scholtz B, Brázda P, Ghyselinck N, Chambon P, Fésüs L,Szondy Z. Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription. Cell Death Differ.May;18(5):783-92 (2011)
              2.  Miko E, Margitai Z, Czimmerer Z, Várkonyi I, Dezső B, Lányi A, Bacsó Z, Scholtz B. miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5. FEBS Lett. 585(8):1191-1196. (2011)
              3. Poliska S, Csanky E, Szanto A, Szatmari I, Mesko B, Szeles L, Dezso B, Scholtz B, Podani J, Kilty I, Takacs L, Nagy L. Chronic Obstructive Pulmonary Disease-Specific Gene Expression Signatures of Alveolar Macrophages as well as Peripheral Blood Monocytes Overlap and Correlate with Lung Function. Respiration. 81(6):499-510 (2011)
              4. Penyige A, Poliska S, Csanky E, Scholtz B, Dezso B, Schmelczer I, Kilty I,Takacs L, Nagy L. Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study. BMC Med Genet. 11:152. (2010)
              5. Varga I, Hutóczki G, Petrás M, Scholtz B, Miko E, Kenyeres A, Tóth J, Zahuczky G, Bognár L, Hanzély Z, Klekner A. Expression of invasion-related extracellular matrix molecules in human glioblastoma versus intracerebral lung adenocarcinoma metastasis. Cen Eur Neurosurg. 71(4):173-80. (2010)
              6. Inczédy-Farkas G, Benkovits J, Balogh N, Almos P, Scholtz B, Zahuczky G, Török Z, Nagy K, Réthelyi J, Makkos Z, Kassai-Farkas A, Egerházy A, Tuzko J, Janka Z, Bitter I, Németh G, Nagy L, Molnár MJ. SCHIZOBANK - The Hungarian national schizophrenia biobank and its role in schizophrenia research and in personalized medicine. Orv Hetil. 151(35):1403-8. (2010)
              7. Klekner A, Varga I, Bognár L, Hutóczki G, Kenyeres A, Tóth J, Hanzély Z, Scholtz B. Extracellular matrix of cerebral tumors with different invasiveness. Ideggyogy Sz. 63(1-2):38-43. (2010)
              8. Miko E, Czimmerer Z, Csánky E, Boros G, Buslig J, Dezso B, Scholtz B. Differentially expressed microRNAs in small cell lung cancer. Exp Lung Res. 35(8):646-64. (2009)
              9. Petrás M, Hutóczki G, Varga I, Vereb G, Szöllosi J, Bognár L, Ruszthi P, Kenyeres A, Tóth J, Hanzély Z, Scholtz B, Klekner A. Expression pattern of invasion-related molecules in brain tumors of different origin. Magy Onkol. 53(3):253-8. (2009)
              10. Csanky E, Rühl R, Scholtz B, Vasko A, Takacs L, Hempel WM. Lipid metabolite levels of prostaglandin D2 and eicosapentaenoic acid recovered from bronchoalveolar lavage fluid correlate with lung function of chronic obstructive pulmonary disease patients and controls. Electrophoresis. (7):1228-34. (2009)


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